Functions of Cerebrospinal FluidCerebrospinal fluid is an ultrafiltrate of plasma that surrounds the brain and spinal cord.
It serves three main functions:
- Protection – It acts as a cushion for the brain, limiting neural damage in cranial injuries.
- Buoyancy – By being immersed in CSF, the net weight of the brain is reduced to approximately 25 grams. This prevents excessive pressure on the base of the brain.
- Chemical stability – The CSF creates an environment to allow for proper functioning of the brain, e.g. maintaining low extracellular K+ for synaptic transmission .
The Ventricles of the BrainThe ventricles are structures that produce cerebrospinal fluid, and transport it around the cranial cavity. They are lined by ependymal cells, which form a structure called the choroid plexus. It is within the choroid plexus that CSF is produced.
Embryologically, the ventricular system is derived from the lumen of the neural tube.
DON'T MISS: CLINICAL CASE ON HYDROCEPHALUS
In total, there are four ventricles; right and left lateral ventricles, third ventricle and fourth ventricle.
The left and right lateral ventricles are located within their respective hemispheres of the cerebrum. They have ‘horns’ which project into the frontal, occipital and temporal lobes. The volume of the lateral ventricles increases with age.
The lateral ventricles are connected to the third ventricle by the foramen of Monro. The third ventricle is situated in between the right and the left thalamus. The anterior surface of the ventricle contains two protrusions:
- Supra-optic recess – located above the optic chiasm.
- Infundibular recess – located above the optic stalk.
The fourth ventricle is the last in the system – it receives CSF from the third ventricle via the cerebral aqueduct. It lies within the brainstem, at the junction between the pons and medulla oblongata.
From the 4th ventricle, the fluid drains into two places:
- Central spinal canal – Baths the spinal cord
- Subarachnoid cisterns – Baths the brain, between arachnoid mater and pia mater. Here the CSF is reabsorbed back into the circulation.
Production and Reabsorption of Cerebrospinal FluidCerebrospinal fluid is produced by the choroid plexus, located in the lining of the ventricles. It consists of capillaries and loose connective tissue, surrounded by cuboidal epithelial cells. Plasma is filtered from the blood by the epithelial cells to produce CSF. In this way, the exact chemical composition of the fluid can be controlled.
Drainage of the CSF occurs in the subarachnoid cisterns (or space). Small projections of arachnoid mater (called arachnoid granulations), protrude into the dura mater. They allow the fluid to drain into the dural venous sinuses.
Clinical Relevance: HydrocephalusHydrocephalus is defined as an abnormal collection of CSF within the ventricles of the brain. It is a serious condition, with chronic hydrocephalus causing raised intracranial pressure, and consequently cerebral atrophy.
Based on the underlying cause, there are two clinical classifications:
- Communicating (Non-obstructive) Hydrocephalus – Abnormal collection of CSF in the absence of any flow obstruction in the ventricles. Common causes usually involve the functional impairment of the arachnoid granulations, such as fibrosis of the subarachnoid space following a haemorrhage.
- Non-communicating (Obstructive) Hydrocephalus – Abnormal collection of CSF, with flow obstructed within the ventricular system. The most common site of obstruction is the cerebral aqueduct, connecting the third and fourth ventricles.
Treatment of hydrocephalus primarily involves reversing the cause. Whilst treating the cause, a shunt can be inserted, which drains the fluid into the right atrium or the peritoneum.